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產品介紹 當前位置:首頁 > 產品介紹 > 新陳代謝系列

類型: 新陳代謝系列

名稱:冷卻系統

CCS2000 Chiller System

型號:CCS2000

  • 產品介紹
  • 產品特點
  • 產品參數
  • 產品應用
  • 文獻參考

CCS2000冷卻系統設計用于冷藏并保持的代謝籠樣品在或低于45華氏度(7攝氏度)。

 

產品由三部分組成:
1)15個MMC100小鼠代謝籠;
2)籠架;
3)冷卻裝置。
它是為我們的標準代謝籠和籠架而設計的,因此,它提供了所有hatteras產品相同的質量和功能保證。

 

使用要求:
盡管該系統是精心設計制作的,但是它的使用時很簡單的。安裝過程包括:將絕緣底座插入連接端口,將代謝籠放置到籠架上,給水槽中注水,和啟動系統。就是這樣。系統將自動開始制冷,以及維持與周圍溫度(室溫)30度左右的溫差。系統是可靠的和耐用的,不需要特殊的維護。

 

安裝開始于制冷單元,制冷單元安裝在籠架的底部,包含電子單元用來制冷和維持水的溫度。還包括水槽,用來實現水循環。另外,該單元還包括一個控制器用來顯示和控制溫度水平。

 

籠架系統是一個支撐設施,包含鉛管系統和制冷單元,作為代謝籠的連接點?;\架是鋁質的,帶有烤漆。3排水平結構,每個水平結構上帶有5個小孔用來安裝代謝籠。每一排的旁邊的背板上是連接的端口,用來連接代謝籠的絕緣底座到鉛管。制冷的絕緣底座為尿液樣本提供制冷?;\子由丙烯酸零部件和不銹鋼底板和獨特設計的不銹鋼收集漏斗組成??梢允孢m的安全的連續24小時飼養一只小鼠,制冷的代謝籠提供和標準的代謝籠一樣的收集能力。

 

產品優勢:
冷卻尿液樣本將確保幾個用于研究的好處:
1 保持樣品的質量;
2 消除細菌繁殖;
3 維持一個穩定的pH值;
4 保持樣本的活性;
此外,制冷過程可保持溫暖環境氣候中的籠內環境冷卻,從而為老鼠提供更舒適的空氣。

 

產品優勢:
冷卻尿液樣本將確保幾個用于研究的好處:
1 保持樣品的質量;
2 消除細菌繁殖;
3 維持一個穩定的pH值;
4 保持樣本的活性;
此外,制冷過程可保持溫暖環境氣候中的籠內環境冷卻,從而為老鼠提供更舒適的空氣。

CCS2000冷卻系統設計用于冷藏并保持的代謝籠樣品在或低于45華氏度(7攝氏度)。

Oral Candidaadministration in a Clostridium difficile mouse model worsens disease severitybut is attenuated by Bifidobacterium Wimonrat Panpetch, Naraporn Somboonna, +4 authors Asada Leelahavanichkul  PloS one2019

Gut fungi may influence the course of Clostridiumdifficile infection either positively or negatively for the host. Fungi are notprominent in the mouse gut, and C. albicans, the major human… (More)

 

The Role ofAngiotensin II in Experimental Acute Kidney Injury and Cardiorenal Failure  Sofia J?nsson 2019

J?nsson, S. 2019. The Role of Angiotensin II inExperimental Acute Kidney Injury and Cardiorenal Failure. Digital ComprehensiveSummaries of Uppsala Dissertations from the Faculty of Medicine 1554.… (More)

 

The HormoneFGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol.  Parkyong Song, Christoph Zechner, +11 authors Steven Anthony Kliewer  Cell metabolism  2018

Alcohol and ketogenic diets increase waterconsumption. Here, we show that the hormone FGF21 is required for this drinkingresponse in mice. Circulating levels of FGF21 are increased by alcohol… (More)

 

The Synergy ofEndotoxin and (1→3)-β-D-Glucan, from Gut Translocation, Worsens Sepsis Severityin a Lupus Model of Fc Gamma Receptor IIb-Deficient Mice. Jiraphorn Issara-Amphorn, Saowapha Surawut, +7 authors Asada Leelahavanichkul  Journal ofinnate immunity  2018

We investigated the influence of spontaneous gutleakage upon polymicrobial sepsis in a lupus model with Fc gamma receptorIIb-deficient (FcGRIIb-/-) mice aged 8 and 40 weeks, as representing… (More)

 

A companion tothe preclinical common data elements for physiologic data in rodent epilepsymodels. A report of the TASK3 Physiology Working Group of the ILAE/AES JointTranslational Task Force  Jan A. Gorter, Erwin A. van Vliet, +7 authors Astrid Nehlig Epilepsia open  2018

The International League Against Epilepsy/AmericanEpilepsy Society (ILAE/AES) Joint Translational Task Force created the TASK3working groups to create common data elements (CDEs) for various… (More)

 

Remote ischemicpost-conditioning promotes hematoma resolution via AMPK-dependent immuneregulation  Kumar Vaibhav, Molly Braun, +15 authors Krishnan M Dhandapani  TheJournal of experimental medicine  2018

Spontaneous intracerebral hemorrhage (ICH) producesthe highest acute mortality and worst outcomes of all stroke subtypes. Hematomavolume is an independent determinant of ICH patient outcomes,… (More)

 

Increasedsusceptibility against Cryptococcus neoformans of lupus mouse models(pristane-induction and FcGRIIb deficiency) is associated with activatedmacrophage, regardless of genetic background  Saowapha Surawut, Jiradej Makjaroen, +5 authors Asada Leelahavanichkul  Journal ofMicrobiology  2018

The severity of cryptococcosis in lupus from varyinggenetic-backgrounds might be different due to the heterogeneity oflupus-pathogenesis. This study explored cryptococcosis in lupus mouse modelsof… (More)

 

Mitochondrialuncoupling has no effect on microvascular complications in type 2 diabetes  Lucy M Hinder, Kelli M Sas, +11 authors Eva L. Feldman Scientific Reports   2018

Diabetic peripheral neuropathy (DPN), diabetic kidneydisease (DKD), and diabetic retinopathy (DR) contribute to significantmorbidity and mortality in diabetes patients. The incidence of these… (More)

 

BrainPhospholipid Precursors Administered Post-Injury Reduce Tissue Damage andImprove Neurological Outcome in Experimental Traumatic Brain Injury  Orli Thau-Zuchman, Rita N. Gomes, +6 authors Adina Teodora Michael-Titus  Journal ofneurotrauma  2018

Traumatic brain injury (TBI) leads to cellular loss,destabilization of membranes, disruption of synapses and altered brainconnectivity, and increased risk of neurodegenerative disease. A… (More)

 

Chronic InsulinInfusion Down-Regulates Circulating and Urinary Nitric Oxide (NO) LevelsDespite Molecular Changes in the Kidney Predicting Greater Endothelial NOSynthase Activity in Mice  Maurice Bruce Fluitt, Sophia Rizvi, +4 authors Carolyn M A Ecelbarger  Internationaljournal of molecular sciences  2018

Insulin therapy is often needed to overcome insulinreceptor resistance in type 2 diabetes; however, the impact of providingadditional insulin to already hyperinsulinemic subjects is not clear. We… (More)

 

Telmisartan prevents diet-induced obesity and preservesleptin transport across the blood-brain barrier in high-fat diet-fed mice  Franziska Schuster, Gianna Huber, +5 authors Walter Raasch Pflügers Archiv - European Journal ofPhysiology  2018

Obesity is a global health problem and treatmentoptions are still insufficient. When chronically treated with the angiotensinII receptor blocker telmisartan (TEL), rodents do not develop… (More)

 

Thymosin β4Deficiency Exacerbates Renal and Cardiac Injury in Angiotensin-II-InducedHypertension.  Naveen P. G. Kumar, Tang-dong Liao, Cesar A Romero, Mani Maheshwari, Edward L. Peterson, Oscar A. Carretero  Hypertension  2018

Thymosin β4 (Tβ4), a ubiquitous peptide, regulatesseveral cellular processes that include cell morphology, wound healing, andinflammatory response. Administration of exogenous Tβ4 is protective in… (More)

 

Experimentalautoimmune encephalomyelitis (EAE) up-regulates the mitochondrial activity andmanganese superoxide dismutase (MnSOD) in the mouse renal cortex  Balamurugan Packialakshmi, Xiaoming Zhou PloS one  2018

Increases of the activity of mitochondrial electrontransport chain generally lead to increases of production of ATP and reactiveoxygen species (ROS) as by-products. MnSOD is the first line of… (More)

 

In VivoAnticancer Activity of a Nontoxic Inert Phenolato Titanium Complex: HighEfficacy on Solid Tumors Alone and Combined with Platinum Drugs  Nitzan Ganot, Ori Briaitbard, Asaad Gammal, Joseph Tam, Jacob Hochman, Edit Y Tshuva ChemMedChem  2018

Due to the toxicity of platinum compounds used in theclinic as anticancer chemotherapies, titanium serves as a safe and attractivealternative. Lately, we introduced a new family of Ti complexes… (More)

 

RSK2 contributesto myogenic vasoconstriction of resistance arteries by activating smooth musclemyosin and the Na+/H+ exchanger Mykhaylo V Artamonov, Swapnil K. Sonkusare, +8 authors Avril V Somlyo  Science Signaling  2018

Smooth muscle contraction is triggered whenCa2+/calmodulin-dependent myosin light chain kinase (MLCK) phosphorylates theregulatory light chain of myosin (RLC20). However, blood vessels from… (More)

 

Proreninindependently causes hypertension and renal and cardiac fibrosis incyp1a1-prorenin transgenic rats Guangyu Zhou, Jie Wu, +4 authors Yufeng Huang  Clinical science  2018

Plasma prorenin is commonly elevated in diabeticpatients and appears to predict the development of diabetic nephropathy.However, the pathological role of prorenin is unclear. In the presentstudy,… (More)

 

Enhanced RenalIschemia-Reperfusion Injury in Aging and Diabetes.  Yoshikazu Muroya, Xiaochen He, +4 authors Richard Joseph Roman  American journalof physiology. Renal physiology  2018

The incidence and severity of acute kidney injury isincreased in diabetic patients and with aging. However, the mechanisms involvedhave not been clearly established. The present study examined the… (More)

 

SweetTasteReceptors Mediated ROS-NLRP3 Inflammasome Signaling Activation:Implications forDiabetic Nephropathy

Luping ZhouWei Huang, +9 authors Yong Xu  Journal of diabetes research  2018

Previous studiesdemonstratedthat ROS-NLRP3 inflammasome signaling activation was involved inthepathogenesis of diabetic nephropathy (DN). Recent research has shown thatsweettaste receptors… (More)

 

Sesamin alleviates blood-brain barrierdisruption inmice with experimental traumatic brain injury

Ying-liang LiuZhi-ming Xu, +5 authors Heng-Li Tian Acta Pharmacologica Sinica  2017

Sesamin, a majorlignan of sesameoil, was reported to have neuroprotective effects in severalbrain injurymodels. However, its protective action in maintaining blood-brainbarrier (BBB)integrity… (More)

 

Generation and phenotypic analysis ofmice lacking allurea transporters.

Tao JiangYingjie Li, +5 authors Baoxue Yang  Kidney international  2017

Ureatransporters (UT) are afamily of transmembrane urea-selective channel proteinsexpressed in multipletissues and play an important role in the urineconcentrating mechanism of themammalian… (More)

 

miR-155 Deficiency AmelioratesAutoimmune Inflammationof Systemic Lupus Erythematosus by Targeting S1pr1 inFaslpr/lpr Mice.  

Qian XinJiangxia Li, +12 authors Qi-ji Liu  Journal of immunology  2015

MicroRNA-155(miR-155) waspreviously found involved in the development of systemic lupuserythematosus(SLE) and other autoimmune diseases and the inflammatoryresponse; however, thedetailed… (More)

 

MYH9 E1841K Mutation AugmentsProteinuria and PodocyteInjury and Migration.  Sylvia CechovaFan DongFang Cheng ChanMichael J. KelleyP. RuizThu H Le  Journal of the American Society ofNephrology…  2018

Intronicvariants of the MYH9gene that encodes the nonmuscle myosin heavy chain IIA areassociated withdiabetic nephropathy in European Americans and with sicklecelldisease-associated… (More)

 

High salt intake reprioritizes osmolyteand energymetabolism for body fluid conservation.

Kento KitadaSteffen Daub, +21 authors Jens M. Titze  The Journal of clinical investigation  2017

Natriureticregulation ofextracellular fluid volume homeostasis includes suppression ofthe renin-angiotensin-aldosteronesystem, pressure natriuresis, and reducedrenal nerve activity, actionsthat… (More)

 

Podocyte-specific knockout ofcyclooxygenase 2exacerbates diabetic kidney disease.

Liming WangYonggang Sha, +4 authors Robert F Spurney  American journal of physiology. Renalphysiology  2017

Enhancedexpression ofcyclooxygenase 2 (COX2) in podocytes contributes to glomerularinjury indiabetic kidney disease, but some basal level of podocyte COX2expression mightbe required to promote… (More)

 

From Newborn to SenescenceMorphological andFunctional Remodeling Leads to Increased Contractile Capacityof Arteries.

Ivan Ivi?Zoltán VámosPeter Cseploákos Koller  The journals of gerontology. Series A,Biological…  2017

Aging inducessubstantialmorphological and functional changes in vessels. We hypothesizedthat due tomorphological remodeling the total contractile forces of arteriesincrease,especially in older… (More)

 

Acute genetic ablation of pendrinlowers bloodpressure in mice.  Francesco TrepiccioneChristelle Soukaseum, +10 authors Dominique Eladari  Nephrology, dialysis, transplantation :official…  2017

BackgroundPendrin, thechloride/bicarbonate exchanger of β-intercalated cells of therenal connecting tubuleand the collecting duct, plays a key role in NaClreabsorption by the distalnephron.… (More)

 

Simultaneous detection of thetetrachloroethylenemetabolites S-(1,2,2-trichlorovinyl)glutathione,S-(1,2,2-trichlorovinyl)-L-cysteine,andN-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine in multiple…

Yu-Syuan LuoJoseph A. CichockiT. J. McDonaldIvan Rusyn Journal of toxicology andenvironmentalhealth…  2017

Tetrachloroethylene(perchloroethylene;PERC) is a high-production volume chemical and ubiquitousenvironmental contaminantthat is hazardous to human health. Toxicityattributed to PERC ismediated… (More)

 

Marine Animal Forests

Sabrina H RossiLorenzo BramantiAndrea GoriCovadonga Orejas  Springer International Publishing  2017

In the marinebenthos,megabenthic communities dominated by sessile sus-pensionfeeders (such assponges, corals, and bivalves) formthree-dimensionalstructures which providearchitectural… (More)

 

Effects ofN‐acetyl‐seryl‐asparyl‐lysyl‐proline onblood pressure, renal damage, andmortality in systemic lupus erythematosus

Pablo NakagawaJuan X. Masjoan‐Juncos, +6 authors Oscar A. Carretero  Physiological reports  2017

Systemic lupuserythematosus(SLE) is an autoimmune disease with a high prevalence ofhypertension. NZBWF1(SLE-Hyp) mice develop hypertension that can be preventedby modulating T cells.The peptide… (More)

 

Chronic PARP-1 inhibition reducescarotid vesselremodeling and oxidative damage of the dorsal hippocampus inspontaneouslyhypertensive rats

Krisztián Er?sKlara Magyar, +8 authors Robert Halmosi PloS one 2017

Vascularremodeling duringchronic hypertension may impair the supply of tissues withoxygen, glucose andother compounds, potentially unleashing deleteriouseffects. In this study, weused… (More)

 

, David Webb , Yuri Kotelevtsev andretention and Breceptors causes hypertension and sodium Combined knockout ofcollecting ductendothelin A

Donald E KohanYuqiang Ge, +18 authors Brian D. Cain  2017

 

Radiobiology and Radiation Hormesis

Dr. Charles L. Sanders  Springer International Publishing  2017

 

 

Human umbilical cord Wharton jellycells promoteextra-pancreatic insulin formation and repair of renal damage inSTZ-induceddiabetic mice  Martin MaldonadoTian-hua HuangLujun YangLan XuLian Ma  Cell Communication and Signaling  2017

We evaluated thetherapeuticeffect and fate of high doses of human umbilical cord Wharton jellycells(hUCWJCs) after IP administration to streptozotocin (STZ)-induceddiabetic mice.Type 1 diabetes… (More)

 

Direct and IndirectMineralocorticoidEffects Determine Distal Salt Transport.

AndrewScott TerkerBethzaidaYarbrough+7 authorsDavidH. Ellison  Journal of theAmerican Society ofNephrology…  2016

Excess aldosterone isanimportant contributor to hypertension and cardiovascular disease.Conversely,low circulating aldosterone causes salt wasting and hypotension.Aldosteroneactivates… (More)

 

A time-courseanalysis of changes incerebral metal levels following a controlled corticalimpact.

StuartD. PortburyDominicJ. HareCharlotteJ SgambelloniDavidI FinkelsteinPaulA. Adlard  Metallomics :integrated biometal science 2016

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